Subscribe to our newsletter

The best bets and resources to make you more profitable


Cubs vs. Pirates Predictions, Betting Odds, Picks – Saturday, September 24, 2022

<p>AP Photos</p>

AP Photos


OddsJam’s MLB experts take you through the betting odds, picks and predictions for this MLB matchup between the Chicago Cubs vs. the Pittsburgh Pirates on September 24, 2022 in Pittsburgh.

The OddsJam Positive EV Betting Tool is the only offering with a live data feed that identifies mathematically profitable betting opportunities in real time.

Chicago Cubs Moneyline-120
Pittsburgh Pirates Moneyline+100
Chicago Cubs Run Line-1.5, +145
Pittsburgh Pirates Run Line+1.5, -170
CubsPirates Over/Under6.5
Date & TimeSeptember 24, 2022 at 6:35 p.m. ET / 3:35 p.m. PT

Opening Lines via DraftKings Sportsbook

As a note, all odds in this preview of Cubs vs. Pirates are from the opening lines. Odds can move at any time. Please check the table below for real-time betting odds!

The Chicago Cubs visit the Pittsburgh Pirates for this MLB matchup on September 24, 2022. First pitch for Saturday’s game is 6:35 p.m. ET / 3:35 p.m. PT in Pittsburgh.

The Chicago Cubs are favored at -120 vs. the Pittsburgh Pirates. The Pittsburgh Pirates are +100 underdogs on the moneyline in this matchup and are +1.5 on the run line at -170.

The over/under for this matchup between the Cubs and the Pirates is set at 6.5, with the over 6.5 at -125 and the under 6.5 at +105.

Download OddsJam’s player prop betting app today to find the player props with the best value across every MLB game and market.

Chicago Cubs vs. Pittsburgh Pirates Betting Odds, Over/Under, Run Lines:

TeamMoneylineOver/UnderRun Line
Chicago Cubs-120O 6.5, -125-1.5 +145
Pittsburgh Pirates+100U 6.5, +105+1.5 -170
Odds via DraftKing Sportsbook

Looking to bet on this MLB matchup between the Chicago Cubs and the Pittsburgh Pirates

Use OddsJam’s MLB Odds comparison tool to find the best odds on mainline markets like moneyline, run line and total, as well as every single MLB player prop at all major sportsbooks available in your state!

Want to learn more on how to bet on the MLB? You can find our MLB Betting Guide, our MLB Prop Betting Guide and much more in our Betting Education hub.

Subscribe to our newsletter

The best bets and resources to make you more profitable


Worth $4,011

BetMGM logo

Get a $1,500 Bonus First Bet!

Betfred logo

Bet $50, Get a $111 Bonus + Up To $1,000 Over 5 Weeks!

Caesars logo

Get up to $1,000 Back in Bonus Bets if Your First Bet Doesn't Win!

FanDuel logo

Bet $5, Get $200 in Bonus Bets

DraftKings logo

Bet $5 on Any Market, Get $200 Instantly!


  1. Who is the favorite in Chicago Cubs vs Pittsburgh Pirates?

    The Chicago Cubs are favored to win this MLB matchup, priced at -120 moneyline odds. The game will take place on September 24, 2022 in Pittsburgh.

  2. What are the predictions for Chicago Cubs vs Pittsburgh Pirates game?

    The Chicago Cubs are predicted to win this MLB game. Upsets happen all the time in the MLB, but the Chicago Cubs are favored by all online bookmakers. The Pittsburgh Pirates are predicted to lose this game according to betting markets.

  3. Where can I bet on this game?

    You can bet on this game on a variety of sportsbooks, including Caesars, BetMGM and FanDuel. The more books you sign up for, the better odds you can find!

Free Bets in Virginia