NFL Best Bets Week 4 Thursday Night Football Cowboys vs Giants

We’ve got a great Thursday Night NFL Week 4 matchup and I’m here to break down the top bets, giving you insights into why each play has value. These bets aren’t just random picks — they’re well-researched based on matchups, volume, and the info I’ve shared with you before.

Let’s dive into today’s key matchups and find the best value plays to get you ready to cash in.

1. CeeDee Lamb Anytime TD (+105 on Fliff)

Matchup: Dallas Cowboys vs. New York Giants
Analysis:
CeeDee Lamb is coming off a few quiet weeks, but he’s due for a breakout. The Cowboys are struggling to run the ball effectively, and their offensive line is built to protect Dak Prescott, setting up a pass-heavy game script. Lamb has the most touchdown equity on the team — his red-zone usage is significant, and the Giants’ defense has been vulnerable in coverage. He’s already proven himself in prime-time games, and tonight feels like the perfect time for a TD from “TD Lamb.”

• Why it’s a Best Bet: Lamb has scored in three straight prime-time games, and with Prescott likely airing it out, he’s the top red-zone target.
• Suggested Bet: CeeDee Lamb Anytime TD (+105 on Fliff)

2. Malik Neighbors Longest Reception Over 22.5 Yards

Matchup: New York Giants vs. Dallas Cowboys
Analysis:
Malik Neighbors has been a target magnet this season with 37 targets in three games, averaging 12 targets per game. He’s been a big-play machine, recording a 25+ yard reception in every game so far this season. Even with Daniel Jones under center, Neighbors’ explosive ability after the catch makes this bet stand out. The Cowboys’ secondary is solid, but Neighbors’ volume and knack for stretching the field make him a prime candidate to hit the over on this line.

• Why it’s a Best Bet: High target share + consistent big plays = great value on this prop.
• Suggested Bet: Malik Neighbors Longest Reception Over 22.5 Yards

3. Dak Prescott Over 259.5 Passing Yards

Matchup: Dallas Cowboys vs. New York Giants
Analysis:
The Cowboys’ running game has been inconsistent, forcing them to rely heavily on Prescott’s arm. The Giants have shown weaknesses in their secondary, and Prescott has the weapons in Lamb and others to exploit this matchup. With the game script likely leaning toward a pass-heavy approach, Prescott going over 259.5 yards feels like a safe play.

• Why it’s a Best Bet: The Cowboys’ offensive line is built to protect Prescott, and the Giants struggle to defend against the pass. Expect Dak to air it out.
• Suggested Bet: Dak Prescott Over 259.5 Passing Yards

4. Parlay Play: Lamb Anytime TD + Prescott Over 259.5 Yards + Neighbors Over 73.5 Receiving Yards (+443)

If you’re feeling adventurous, combining these three bets offers a high-reward opportunity. Each of these individual bets has strong justification, and the synergy between Prescott’s passing yards and Lamb’s touchdown potential makes this parlay a compelling option. Neighbors adds that extra layer with his reliable yardage totals.

• Why it’s a Best Bet: This parlay covers multiple angles of tonight’s game, and all bets align with the expected game flow.
• Suggested Bet: Parlay — Lamb Anytime TD + Prescott Over 259.5 Yards + Neighbors Over 73.5 Yards (+443)

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Today’s slate has some exciting plays, and the bets listed above all offer solid value based on matchups, volume, and past performance. Let’s lock these in and cash out!