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Diamondbacks vs. Astros Predictions, Betting Odds, Picks – Wednesday, September 28, 2022


OddsJam’s MLB experts take you through the betting odds, picks and predictions for this MLB matchup between the Arizona Diamondbacks vs. the Houston Astros on September 28, 2022 in Houston.

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Houston Astros Moneyline-215
Arizona Diamondbacks Moneyline+185
Houston Astros Run Line-1.5, +115
Arizona Diamondbacks Run Line+1.5, -135
DiamondbacksAstros Over/Under6.5
Date & TimeSeptember 28, 2022 at 8:10 p.m. ET / 5:10 p.m. PT

Opening Lines via DraftKings Sportsbook

As a note, all odds in this preview of Diamondbacks vs. Astros are from the opening lines. Odds can move at any time. Please check the table below for real-time betting odds!

The Arizona Diamondbacks visit the Houston Astros for this MLB matchup on September 28, 2022. First pitch for Wednesday’s game is 8:10 p.m. ET / 5:10 p.m. PT in Houston.

The Houston Astros are favored at -215 vs. the Arizona Diamondbacks. The Arizona Diamondbacks are +185 underdogs on the moneyline in this matchup and are +1.5 on the run line at -135.

The over/under for this matchup between the Diamondbacks and the Astros is set at 6.5, with the over 6.5 at +100 and the under 6.5 at -120.

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Arizona Diamondbacks vs. Houston Astros Betting Odds, Over/Under, Run Lines:

TeamMoneylineOver/UnderRun Line
Arizona Diamondbacks+185O 6.5, +100+1.5 -135
Houston Astros-215U 6.5, -120-1.5 +115
Odds via DraftKing Sportsbook

Looking to bet on this MLB matchup between the Arizona Diamondbacks and the Houston Astros

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  1. Who is the favorite in Arizona Diamondbacks vs Houston Astros?

    The Houston Astros are favored to win this MLB matchup, priced at -215 moneyline odds. The game will take place on September 28, 2022 in Houston.

  2. What are the predictions for Arizona Diamondbacks vs Houston Astros game?

    The Houston Astros are predicted to win this MLB game. Upsets happen all the time in the MLB, but the Houston Astros are favored by all online bookmakers. The Arizona Diamondbacks are predicted to lose this game according to betting markets.

  3. Where can I bet on this game?

    You can bet on this game on a variety of sportsbooks, including Caesars, BetMGM and FanDuel. The more books you sign up for, the better odds you can find!

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