Diamondbacks vs. Astros Predictions, Betting Odds, Picks – Tuesday, September 27, 2022

OddsJam’s MLB experts take you through the betting odds, picks and predictions for this MLB matchup between the Arizona Diamondbacks vs. the Houston Astros on September 27, 2022 in Houston.

Opening Lines via DraftKings Sportsbook

As a note, all odds in this preview of Diamondbacks vs. Astros are from the opening lines. Odds can move at any time. Please check the table below for real-time betting odds!

The Arizona Diamondbacks visit the Houston Astros for this MLB matchup on September 27, 2022. First pitch for Tuesday’s game is 8:10 p.m. ET / 5:10 p.m. PT in Houston.

The Houston Astros are favored at -230 vs. the Arizona Diamondbacks. The Arizona Diamondbacks are +195 underdogs on the moneyline in this matchup and are +1.5 on the run line at -115.

The over/under for this matchup between the Diamondbacks and the Astros is set at 7.5, with the over 7.5 at -115 and the under 7.5 at -105.

Arizona Diamondbacks vs. Houston Astros Betting Odds, Over/Under, Run Lines:

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