Sharp NFL Picks for Monday Night Football: Breaking Down Titans vs. Bills & Vikings vs. Eagles Week 2 MNF Showdowns

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Alexander SuttonSeptember 19, 2022 at 08:00 PM

Monday Night Football is nearly upon us! For Week 2’s MNF showdowns, we have a doubleheader! The Tennessee Titans will be taking on the Buffalo Bills at Highmark Stadium and the Minnesota Vikings will be taking on the Philadelphia Eagles at Lincoln Financial.

We have three picks for this matchup — here are the sharp bets from OddsJam to lock in now!

Titans vs. Bills Monday Night Football Sharp Picks

Monday, Sept. 19 | 7:15 p.m. ET

Derrick Henry Anytime Touchdown | +115 at DraftKings

It was a quiet start to 2022 for the King. Derrick Henry had 82 rushing yards against the Giants, but that came on 21 attempts (3.9 YPC).

The Giants were missing two key edge defenders in Kayvon Thibodeaux and Azeez Ojulari, yet still managed to keep Henry in check. It certainly wasn’t a great performance from the Titans offensive line.


After being the AFC’s No. 1 seed in 2021, the Titans are in danger of falling to 0-2. They will almost certainly rely on Henry to control the game and keep Buffalo’s offense off the field. It isn’t often that one can get an anytime Henry prop bet at plus-odds, so it’s best to capitalize on this one while you can.

The Titans met the Bills last year and Henry had a signature performance. The King totaled 143 rushing yards and three touchdowns, which gave Tennessee a close victory. Here, we get him to score just once at +115. Take this prop and run with it.

Titans +10 | -110 at Caesars

Based on the predictions I’ve seen throughout the week, this is not a popular pick.

The Bills are riding a high from last week’s blowout win over the Los Angeles Rams, and rightfully so. The Bills look every part of the Super Bowl contender they are touted to be.

However, 10 points is a lot in the NFL. Particularly for the Titans — a team that has given the Bills some trouble the past few seasons. While the team has regressed following the loss of A.J. Brown and Harold Landry, the coaching staff continuity should be enough to keep them as a solid team this year.

As mentioned above, Derrick Henry has been a highlight reel the last two times he’s played Buffalo. I do not expect the Titans to be able to win this game — the Bills are just too good. However, I do believe the lines are overreacting to Tennessee’s loss off a missed game-winning field goal.

Take last year’s No. 1 seed in the AFC to cover this hefty spread.

Minnesota Vikings vs. Philadelphia Eagles Sharp Picks

Monday, Sept. 19 | 8:30 p.m. ET

Eagles Moneyline | Shop for the Best Line Below!

If you follow our picks here at OddsJam, you’d have cashed in on the Vikings moneyline last week. Unfortunately for our friends in Minnesota, we’ll be taking the Eagles this Monday.

The Vikings had a very impressive performance against the Packers, but the Eagles looked very good against the Lions on the road. Despite giving up some concerning late-game points, Philadelphia now has an elite complement of weapons for Jalen Hurts. I locked this in at -130 at Caesars, but be sure to shop for the best lines below.


In his debut with the team, A.J. Brown had 10 receptions for 155 yards. The pairing of him with DeVonta Smith is dangerous and one the Vikings will have to manage.

Similarly, the primary threat to the Eagles is Justin Jefferson, who also had a monster game in Week 1. Philadelphia’s cornerback room, highlighted by Darius Slay and James Bradberry, is better than Minnesota’s. I like Philly’s chances to slow down the opposing star wideouts better.

Vikings quarterback Kirk Cousins has a career record of 1-9 on Monday Night Football. His first win came last year against the lowly Chicago Bears. That’s a record I cannot justify betting on, so we are going to bet against it.

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