Guardians vs. White Sox Predictions, Betting Odds, Picks – Wednesday, September 21, 2022

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OddsJam StaffSeptember 21, 2022 at 01:34 AM

 

OddsJam’s MLB experts take you through the betting odds, picks and predictions for this MLB matchup between the Cleveland Guardians vs. the Chicago White Sox on September 21, 2022 in Chicago.

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TeamOdds
Chicago White Sox Moneyline-130
Cleveland Guardians Moneyline+110
Chicago White Sox Run Line-1.5, +165
Cleveland Guardians Run Line+1.5, -195
GuardiansWhite Sox Over/Under7.5
Date & TimeSeptember 21, 2022 at 8:10 p.m. ET / 5:10 p.m. PT

Opening Lines via DraftKings Sportsbook

As a note, all odds in this preview of Guardians vs. White Sox are from the opening lines. Odds can move at any time. Please check the table below for real-time betting odds!

Moneyline

The Cleveland Guardians visit the Chicago White Sox for this MLB matchup on September 21, 2022. First pitch for Wednesday’s game is 8:10 p.m. ET / 5:10 p.m. PT in Chicago.

The Chicago White Sox are favored at -130 vs. the Cleveland Guardians. The Cleveland Guardians are +110 underdogs on the moneyline in this matchup and are +1.5 on the run line at -195.

The over/under for this matchup between the Guardians and the White Sox is set at 7.5, with the over 7.5 at -105 and the under 7.5 at -115.

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Cleveland Guardians vs. Chicago White Sox Betting Odds, Over/Under, Run Lines:

TeamMoneylineOver/UnderRun Line
Cleveland Guardians+110O 7.5, -105+1.5 -195
Chicago White Sox-130U 7.5, -115-1.5 +165
Odds via DraftKing Sportsbook

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FAQ

  1. Who is the favorite in Cleveland Guardians vs Chicago White Sox?

    The Chicago White Sox are favored to win this MLB matchup, priced at -130 moneyline odds. The game will take place on September 21, 2022 in Chicago.

  2. What are the predictions for Cleveland Guardians vs Chicago White Sox game?

    The Chicago White Sox are predicted to win this MLB game. Upsets happen all the time in the MLB, but the Chicago White Sox are favored by all online bookmakers. The Cleveland Guardians are predicted to lose this game according to betting markets.

  3. Where can I bet on this game?

    You can bet on this game on a variety of sportsbooks, including Caesars, BetMGM and FanDuel. The more books you sign up for, the better odds you can find!

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