San Francisco 49ers vs. Denver Broncos Betting Odds, Picks and Predictions – Sunday, September 25, 2022

<p>AP Photos</p>

AP Photos

OddsJam’s NFL experts take you through the betting odds, picks and predictions for this matchup between the San Francisco 49ers and the Denver Broncos. This game is set to kick off on September 25, 2022. The Denver Broncos are at home for this game.

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San Francisco 49ers vs. Denver Broncos Betting Odds

TeamOdds
Denver Broncos Moneyline-155
San Francisco 49ers Moneyline+130
Denver Broncos Point Spread-3, +100
San Francisco 49ers Point Spread+3, -120
San Francisco 49ersDenver Broncos Over/Under46
Date & TimeSeptember 25, 2022 at 8:20 p.m. ET / 5:20 p.m. PT
Odds via Caesars Sportsbook

The San Francisco 49ers visit the Denver Broncos for this NFL matchup on September 25, 2022. Kickoff for Sunday’s game is 8:20 p.m. ET / 5:20 p.m. PT.

Moneyline

The Denver Broncos are favored at -155 moneyline odds at Caesars. The San Francisco 49ers are +130 underdogs on the moneyline in this matchup vs. the Denver Broncos and +3 on the point spread at -120 odds.

The over/under for this matchup between the San Francisco 49ers and the Denver Broncos is set at 46, with the over 46 at -110 and the under 46 at -110 odds.

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San Francisco 49ers vs. Denver Broncos Betting Odds, Over/Under, Point Spreads:

TeamMoneylineOver/UnderPoint Spread
San Francisco 49ers+130O 46, -110+3 -120
Denver Broncos-155U 46, -110-3 +100
Odds via Caesars Sportsbook

Looking to bet on this NFL matchup between the San Francisco 49ers and the Denver Broncos

Use OddsJam’s sports betting tools to find the best bets on mainline markets like moneyline, point spread and total, as well as every single NFL player prop at all major online sportsbooks available in your location! We recommend CaesarsBetMGMFanDuel and DraftKings.

Want to learn more on how to bet on NFL football? You can find out much more in our Betting Education hub. We also recommend learning about line shopping and Positive EV betting.

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