Giants vs. Rockies Predictions, Betting Odds, Picks – Wednesday, September 21, 2022

OddsJam’s MLB experts take you through the betting odds, picks and predictions for this MLB matchup between the San Francisco Giants vs. the Colorado Rockies on September 21, 2022 in Colorado.

Opening Lines via DraftKings Sportsbook

As a note, all odds in this preview of Giants vs. Rockies are from the opening lines. Odds can move at any time. Please check the table below for real-time betting odds!

The San Francisco Giants visit the Colorado Rockies for this MLB matchup on September 21, 2022. First pitch for Wednesday’s game is 8:40 p.m. ET / 5:40 p.m. PT in Colorado.

The San Francisco Giants are favored at -135 vs. the Colorado Rockies. The Colorado Rockies are +115 underdogs on the moneyline in this matchup and are +1.5 on the run line at -135.

The over/under for this matchup between the Giants and the Rockies is set at 10, with the over 10 at -105 and the under 10 at -115.

San Francisco Giants vs. Colorado Rockies Betting Odds, Over/Under, Run Lines:

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